Comparative study of prevalence of hypothyroidism in cirrhotic patients and normal individuals

Background: Alcoholic cirrhosis has worse prognosis than primary billiary cirrhosis and cirrhosis due to hepatitis. The risk of death due to all cause is increased 12-fold with cirrhosis. Alcoholic liver cirrhosis develops between 10-20% of individuals who drink heavily for a decade or more. Chronic hepatitis B is probably the most common cause of cirrhosis worldwide. The aim and objective of thisstudy was tocompare the prevalence of hypothyroidism between cirrhotic patients andnormal healthy individuals.Methods: The present study constitutes of 50 patients with cirrhosis of liver who met our inclusion criteria. They were selected from the patients admitted in medical wards and gastroenterology ward of RNT medical college, Udaipur.Results: Majority of patients were of serum albumin level class III about 67%. Increased TSH level as compare to level of serum albumin in cirrhotic patients. When serum albumin level decreases then percent of TSH level increases. Majority of patientswere from serum bilirubin class III (71%). Majority were from serum bilirubin class III about 70%. Conclusions: All cirrhotic patients should undergo for evaluation of endocrinological evaluation as these patients are associated with development of hypothyroidism. After diagnosis the treatment of endocrinological disorder especially hypothyroidism may increase survival.

Study of Acid Base and Electrolyte Disturbances in Patients of Acute Myocardial Infarction

Introduction: Myocardial infarction is the main cause of deathin Western countries, with in hospital mortality of 6-13%. Acidbase and electrolyte status in AMI patients at the time ofadmission that can be help in risk stratification and it can helpfor further planning of management strategy for managementof patient with AMI.Aim of Study: To Study of Acid base and electrolytedisturbances in patients of acute myocardial infarction andrelation of Hypokalemia and hypomagnesemia with ventricularArrhythmias in AMI.Materials and Methods: This Observational study wasconducted in the department of Medicine at R.N.T. MedicalCollege and Govt. MB Hospital, Udaipur. Study subjects were50 patients of acute ST segment elevated Myocardial Infarctionpresenting within 24 hrs of onset of chest pain. We estimatedtheir acid base status, serum sodium, serum potassium, serummagnesium.Results: The definite correlation was found between metabolicacidosis and mortality (p=0.03). There was also increasedmortality in patients with hyponatremia, but p value was notstatistically significant (p=0.15). In our study definite correlationfound between hypokalemia and ventricular arrhythmias andalso between hypomagnesemia and ventricular arrhythmiasthere was increased tendency towards developing ventriculararrhythmias in patients with hypokalemia andhypomagnesemias. There was no correlation found betweenhypernatremia and mortality and between increased potassiumlevel and ventricular Arrhythmias in our study